Efficacy of rivastigmine in cognitive functioning
of chronic schizophrenic patients
I. GKOLIA, G. SIATIS, B. KARPOYZA, TH. PANTAZI, E. EYGENIDOY, N. OIKONOMIDIS, A. KANISTRAS
Objective: Cognitive dysfunction is a symptom of schizophrenia responsible for personal and social dysfunction. Neuroleptics, especially classic neuroleptics and anti-cholinergic drugs administered in schizophrenia can additionally aggravate cognitive function by influencing memory function. The aim of this study is to assess the efficacy of rivastigmine in cognitive functioning of chronic schizophrenic patients.
Method: In this study cognitive as well as personal and social functioning of 19 patients with schizophrenia was assessed for a period of six months during which rivastigmine was prescribed. Cognitive, personal and social functioning was assessed by MMSE (Mini Mental Status Examination), IADL (Instrumental Activities of Daily Living), NPI (Neuropsychiatric Inventory) AMTS (Abbreviated Mental Test Score) and Clock test.
Results: Repeated Measures ANOVA was used for the statistical analysis of the test results just before the administration of rivastigmine as well as 3 months and 6 months after the administration of rivastigmine. No statistical differences were observed in memory, concentration and functioning of patients. A slight improvement in MMSE and AMTS was observed (but not statistically important) , possibly because of the chronic cognitive impairment and the limited dosage of rivastigmine. Statistical improvement was observed in Clock test especially in the first trimester. The side-effects were also assessed.
Key words: Rivastigmine, schizophrenia.